What does code 81291 cost?

Across the published hospital price files, the disclosed cash price for 81291 ranges from $37.20 to $772. This is public hospital price transparency data, not a guaranteed estimate of your bill.

Will this be my final bill?

Actual patient responsibility may vary based on your insurance plan, deductible, coinsurance, network status, diagnosis, setting, bundled services, clinical circumstances, and hospital billing practices.

81291 is the billing code hospitals use to identify "HC METHYLTETRA REDUCTASE(MTHFR)" on their published price files. We use it to line up the same service across different hospitals.

Why do prices for this code differ between hospitals?

Each hospital sets its own prices and negotiates separately with each insurer, so the disclosed price for the same code can vary widely from one hospital to another — and even between plans at a single hospital. Comparing the published figures is what this page is for; a difference does not by itself mean one hospital is better or worse.

What this page is not

It is not a quote, a guarantee, or medical advice. It shows what hospitals have published for this code, so you can compare and ask informed questions — your actual cost depends on your insurance, the exact services performed, and the care setting.

81291

HCPCS

HC METHYLTETRA REDUCTASE(MTHFR)

Verified from hospital fileNot a bill estimate

iDirect answer

Based on the latest published hospital price files, code 81291 (HC METHYLTETRA REDUCTASE(MTHFR)) appears at 31 hospitals with disclosed cash prices from $37.20 to $772. This is public hospital price transparency data, not a guaranteed estimate of your bill.

Published-price availability

hospitals publish a price

list this service without a published price

Cash

List

Negotiated

Allowed

A blank price (“—”) means a hospital names this service but did not publish a dollar amount — it is not a free service or a $0 price.

Compare 81291 prices

Filter by hospital, city, setting, or payer — the summary and charts update with your filters.

Based on hospital-published prices verified from each hospital’s own file. Coverage expands as data is verified.

Published cash prices for code 81291 vary by about 21× across the 29 hospitals with disclosed prices here — from $37.20 to $772. Shopping around can matter.

Hospitals

Prices shown

$37.20

Lowest cash

$772

Highest cash

code 81291 cash price31 disclosed · 29 hospitals

$37.20median ~$149$772

Lowest cash price by hospital

Cash price by city

Reflects your current filters.

Cash price by city$37.20 – $97.50

Pleasanton · 1 hospital$37.20
Green Bay · 1 hospital$97.50
Burlington · 1 hospital$97.50
Marinette · 1 hospital$97.50
Fond Du Lac · 1 hospital$97.50
Grafton · 1 hospital$97.50

35 prices shown.

Service	Hospital	Code	List price	Cash price	Negotiated range	Allowed (median)
HC METHYLTETRA REDUCTASE(MTHFR) Inpatient & outpatient	Endeavor Health Edward Hospital	81291 HCPCS	$772	$772	—	—
Mthfr gene Outpatient	Endeavor Health Edward Hospital	81291 HCPCS	—	—	$65.34 – $111	—
Hc Mthfr Gene Analysis, Common Variants Inpatient & outpatient	University of Chicago Medical Center	81291 HCPCS	—	—	—	—
Mthfr gene Outpatient	University of Chicago Medical Center	81291 HCPCS	—	—	—	—
HB HYPERCOAG MTHFR MUTATION Inpatient & outpatient	Endeavor Health Swedish Hospital	81291 HCPCS	$364	$364	—	—
MTHFR GENE ANALYSIS Inpatient	Aurora BayCare Medical Center	81291 CPT	$195	$97.50	$117 – $166	—
MTHFR GENE ANALYSIS Inpatient	Aurora Medical Center Burlington	81291 CPT	$195	$97.50	$117 – $166	—
MTHFR, DNA mutation to QST Inpatient	Munson Healthcare Charlevoix Hospital	81291 CPT	$337	$287	$270 – $337	—
MTHFR, DNA mutation to QST Inpatient	Munson Healthcare Manistee Hospital	81291 CPT	$337	$287	$169 – $852	—
MTHFR GENE ANALYSIS Inpatient	Aurora Medical Center Bay Area	81291 CPT	$195	$97.50	$117 – $165	—
MTHFR GENE ANALYSIS Outpatient	Aurora Medical Center Bay Area	81291 CPT	$195	$97.50	$52.27 – $229	—
MTHFR GENE ANALYSIS Inpatient	Aurora Medical Center Fond du Lac	81291 CPT	$195	$97.50	$117 – $166	—
MTHFR GENE ANALYSIS Outpatient	Aurora Medical Center Fond du Lac	81291 CPT	$195	$97.50	$52.27 – $229	—
MTHFR GENE ANALYSIS Inpatient	Aurora Medical Center Grafton	81291 CPT	$195	$97.50	$117 – $166	—
MTHFR GENE ANALYSIS Inpatient	Aurora Medical Center Kenosha	81291 CPT	$195	$97.50	$117 – $166	—
MTHFR GENE ANALYSIS Inpatient	Aurora Lakeland Medical Center	81291 CPT	$195	$97.50	$117 – $166	—
MTHFR, DNA mutation to QST Inpatient	Kalkaska Memorial Health Center	81291 CPT	$337	$287	$249 – $852	—
MTHFR, DNA mutation to QST Inpatient	Munson Healthcare Cadillac	81291 CPT	$337	$287	$202 – $852	—
MTHFR, DNA mutation to QST Outpatient	Munson Medical Center	81291 CPT	$337	$287	$34.17 – $330	—
HC METHYLENE REDUC MUT DET Inpatient	Deaconess Gibson Hospital	81291 CPT	$203	$108	$108 – $196	—
HC METHYLENE REDUC MUT DET Outpatient	The Women's Hospital	81291 CPT	$856	$505	$26.14 – $728	—
MTHFR GENE Outpatient	Beacon Dowagiac	81291 CPT	—	—	$30.96 – $65.34	—
HC MTHFR GENE ANALYSIS COMMON VARIANTS CDM Inpatient & outpatient	Providence Alaska Medical Center	81291 HCPCS	$950	$741	—	—
HC Mthfr Cmn Var 677 1298 Inpatient & outpatient	Stanford Health Care Tri-Valley	81291 HCPCS	$93.00	$37.20	—	—
HC MTHFR GENE ANALYSIS COMMON VARIANTS CDM Inpatient & outpatient	Petaluma Valley Hospital	81291 HCPCS	$310	$158	—	—

How to read these prices

Cash price: The discounted self-pay price for paying directly, without insurance.
List price: The hospital’s full undiscounted charge — rarely what anyone pays.
Negotiated rate: A rate for a specific insurer and plan; your share depends on your benefits.
Allowed amount: A historical reference for what was actually allowed, where disclosed.

Hospitals that publish 81291 prices

Open a hospital to see this code in the context of its full published prices.

Endeavor Health Edward Hospital University of Chicago Medical Center Endeavor Health Swedish Hospital Aurora BayCare Medical Center Aurora Medical Center Burlington Munson Healthcare Charlevoix Hospital Munson Healthcare Manistee Hospital Aurora Medical Center Bay Area Aurora Medical Center Fond du Lac Aurora Medical Center Grafton Aurora Medical Center Kenosha Aurora Lakeland Medical Center Kalkaska Memorial Health Center Munson Healthcare Cadillac Munson Medical Center Deaconess Gibson Hospital The Women's Hospital Beacon Dowagiac Providence Alaska Medical Center Stanford Health Care Tri-Valley Petaluma Valley Hospital Queen of The Valley Medical Center Redwood Memorial Hospital Providence St Joseph Hospital Eureka Santa Rosa Memorial Hospital Texas Health Center for Diagnostics and Surgery Plano Providence Mission Hospital - Mission Viejo Providence St Joseph Hospital Orange St Jude Medical Center St Mary Medical Center Providence St Joseph Medical Center

Code 81291: frequently asked

What does code 81291 cost?: Across the published hospital price files, the disclosed cash price for 81291 ranges from $37.20 to $772. This is public hospital price transparency data, not a guaranteed estimate of your bill.
Will this be my final bill?: Actual patient responsibility may vary based on your insurance plan, deductible, coinsurance, network status, diagnosis, setting, bundled services, clinical circumstances, and hospital billing practices.
What is code 81291?: 81291 is the billing code hospitals use to identify "HC METHYLTETRA REDUCTASE(MTHFR)" on their published price files. We use it to line up the same service across different hospitals.
Why do prices for this code differ between hospitals?: Each hospital sets its own prices and negotiates separately with each insurer, so the disclosed price for the same code can vary widely from one hospital to another — and even between plans at a single hospital. Comparing the published figures is what this page is for; a difference does not by itself mean one hospital is better or worse.
What this page is not: It is not a quote, a guarantee, or medical advice. It shows what hospitals have published for this code, so you can compare and ask informed questions — your actual cost depends on your insurance, the exact services performed, and the care setting.

All CPT / HCPCS codes Browse hospitals How to read this data

Hospitals publishing code 81291 by state

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